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Group differences were assessed using ANOVA/Kruskal-Wallis tests for continuous variables and chi-squared tests for categorical variables

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Their activity is regulated by various factors, including the RANKL-RANK-OPG signaling pathway, estradiol, various cytokines and calciotropic hormones ( Cigarette smoking creates an imbalance in bone turnover, which leads to lower bone mass and decreased bone mineral density and makes bones prone to osteoporosis and fractures

Unfortunately, as with other addictions, stigma and bias makes it harder for smokers to ask for help, or to help themselves