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On the contrary, the up-regulated genes by overexpression of METTL7A were involved in blastocyst formation at 8-cell stage, tissue development in ICM cells, and voltage- gated potassium and cation channel activities in TE cells, respectively (Figure 2G-I)

Nature 447 , 396398 (2007)

Glyceraldehyde-3-phosphate dehydrogenase (G3PD) inactivation was more exaggerated in the older lenses, diminishing ATP production and having a direct impact on lens transparency