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Together, these mechanisms underpin the scientific rationale for using glutathione in modern skin brightening products, making it a valuable active for serums, essences, creams, and ampoules that focus on safe, gradual, and multidimensional brightening effects

Accordingly, Weiss and coworkers performed a series of experiments to examine the effect of selenium administration (single intraperitoneal injection) through sodium selenite (1.6 mg/kg body weight) or SeM (0.8 to 4 mg/kg body weight) on improving the 30-day survival of mice against lethal doses (910 Gy) of whole body -irradiation (WBI) (Table 2) [42,43,44]

Capsaicin also modulates neurovascular interactions, where sensory neuron-derived peptides such as CGRP stimulate endothelial NO production, further supporting vascular health and resilience (136)

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