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unfortunately, some will be euthanased or die due to the severity of their signs

In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

it is descriptive of what the literature and protocol structure suggest, not a promise of results

An additional office visit will be necessary each year for ongoing therapy or regular intermittent therapy