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Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula (2 mg per mL) is far below such neurotoxic levels

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The 250500 mcg subcutaneous range used in current research contexts sits below the 1 mg clinical trial dose, partly because subcutaneous bioavailability differs from the oral administration used in some trial arms

Who should check with a provider first If you are pregnant, nursing, have kidney disease, or take medications that interact with B12 metabolism (such as metformin), discuss this with a provider before starting