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The growth hormone-releasing activity also makes these hormones attractive performance-enhancing substances, whose usages are banned by the World Anti-Doping Agency in competitive sports 9

GH then acts throughout the body and influences insulin-like growth factor-1 (IGF-1) activity downstream

This may be achieved for instance by selecting the most specific CRISPR effector orthologue or by specific CRISPR effector mutations which increase specificity