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1 H NMR (400 MHz, DMSO- d 6 ) 12.30 (s, 1H), 11.13 (s, 1H), 7.887.72 (m, 2H), 7.62 (t, J = 11.8 Hz, 1H), 7.40 (d, J = 7.1 Hz, 1H), 6.816.66 (m, 1H), 5.12 (dd, J = 12.7, 5.4 Hz, 1H), 4.39 (d, J = 12.7 Hz, 1H), 4.04 (d, J = 14.3 Hz, 2H), 3.93 (d, J = 13.1 Hz, 1H), 3.16 (d, J = 6.4 Hz, 2H), 3.03 (t, J = 12.2 Hz, 1H), 2.932.84 (m, 1H), 2.72 (d, J = 11.2 Hz, 1H), 2.662.53 (m, 3H), 2.39 (d, J = 5.0 Hz, 2H), 2.07 (dd, J = 12.1, 6.8 Hz, 1H), 1.81 (s, 2H), 1.69 (d, J = 6.0 Hz, 4H), 1.55 (d, J = 9.2 Hz, 1H), 1.441.31 (m, 1H), 1.18 (d, J = 4.4 Hz, 9H)

Cellular Stress Resistance In preclinical models, MOTS-c has also been shown to help cells tolerate metabolic and oxidative stress, which is part of the basis for interest in its potential role in aging and age-related disease

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(C) Time-dependent inhibition of TGR activity with GSSG