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Bryrup T, Thomsen CW, Kern T, Allin KH, Brandslund I, Jrgensen NR, Vestergaard H, Hansen T, Hansen TH, Pedersen O, Nielsen T

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

For example, the glutaminase inhibitor BPTES was able to target and inhibit the unique metabolic profile of primary AML cells with IDH mutations (i.e., glutamine addiction), which in turn slowed the growth of primary AML cells with mutant IDH [49]