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Description

This patient's severe hypercholesterolemia indicates massive cholesterol accumulation rather than impaired synthesis, making decreased HMG-CoA reductase activity unlikely

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PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing

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Therefore, altering gut-kidney axis may be a promising therapeutic target for suppressing oxidative stress and inflammation

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doi: 10.1016/S0027-5107(99)00004-4

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