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The induction of angiogenesis in the CNS has been reported to promote pathological conditions such as brain tumor growth, and sterile-venous malformations (SVM) (Vallon and Chang 2014)

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Demonstrating biological activity whether administered systemically, locally, orally, or intraperitoneally in pre-clinical models and and by the breadth of its cytoprotective, tissue repair, and angiogenic effects across virtually every organ system examined in the research literature