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Ischemic cascade Immediately after the reduction in blood flow, oxygen and glucose levels decrease, further reducing adenosine triphosphate and energy-dependent processes [33]

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Acta Crystallogr D Struct Biol 74:8597 Yang L, Antonelli S, Chodankar S, Byrnes J, Lazo E, Qian K (2020) Solution scattering at the life science X-ray scattering (LiX) beamline

In the ATP-binding pocket, the intermediate state had a conformation similar to that of the apo state, despite the drastic movement of the M-HEAT domain upon RHEB binding (Fig