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Caco-2 cells as a model of enterocyte differentiation has been widely used in the past for drug absorption, barrier permeability and toxicological studies ( Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

In addition, the exosomes can provide innovative therapeutic applications such as delivery of chemotherapeutics, siRNA and miRNAs, targeting the certain receptors such as HER2 or integrins on the metastatic lesions as well as controlling the immune reactions

doi: 10.1371/journal.pone.0314750 103 DengLHeSGuoNTianWZhangWLuoL

In synergy with IL-36Ra, IL-36 promotes the intestinal inflammation through the NF-KB pathway, which maintains the homeostasis by balancing the pro- and anti-inflammatory responses in the TME (88)