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According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be considered as an adjunct to lifestyle therapy in all patients with T2DM as needed for weight loss sufficient to improve glycemic control, lipids, and blood pressure

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Other studies have shown a positive impact on fat mass cells [5], fat mass [6], and overall fat distribution [7]

9 Gradual collagenization and calcification of the nucleus occurs, resulting in the degradation and reduction of ECM components in both the AF and NP