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MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases National Institute of Diabetes and Digestive and Kidney Diseases

The IGF-1 axis benefits from the same pause: it drifts back toward baseline instead of sitting chronically elevated, which is the safer position given GH/IGF-1s growth-promoting signaling

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Structural modifications to IGF-1 LR3specifically the inclusion of additional amino acids at the N-terminus and a substitution at position threehave been associated with enhanced receptor affinity