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The predominance of cross-sectional designs precludes causal inference and fails to capture temporal dynamics in microbiome composition (Eskandar, 2025)

Although yet unproven in large cross-section populations, some case-control studies have shown that the active treatment of obesity (by Statins) and/or diabetes (by Metformin) may be beneficial for HCC reduction with odds ratio of 0.74 (95% confidence interval (CI): 0.640.87) and 0.38 (95% CI: 0.240.59), respectively [27, 28]