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This would be consistent with findings that many proteins impacted by APOE genotype in the brain are upregulated in young APOE4 carriers yet downregulated in older individuals with AD (Roberts et al., 2021)

Results: 486 patients were included (mean age 54, range 25 to 85)

In 2018, Jin et al

Eryptosis, MCV and MCHC experiments were performed in Germany (Tbingen), glutathione measurements in Italy (Siena) and the measurements for enzymatic activities in Czech Republic (Olomouc)