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IFN- can also repress the expression of the NAD + -dependent deacetylase SIRT-1 (Li et al., 2012) which is a critical coordinator of cellular metabolism acting primarily by deacetylation

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2011 Dec 1;9(1):216

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Small sample numbers, brief follow-up times, and uneven study endpoints constrain the available evidence[131]

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This is rescued by overexpression of the oncogene ERBB2

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