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Cell signaling in the control of redox homeostasis and cancer Redox-sensitive signaling pathways employ ROS to convey signals from the cell membrane to the nucleus, thereby regulating cellular redox homeostasis (Powers et al

HRD1 inhibitors Pharmacological inhibition of HRD1, a negative regulator of NRF2 implicated in its ubiquitination and degradation, was tested in human liver tissues and in an animal model for the liver cirrhosis characterized by increased ER stress and ROS: LS-102 alleviated liver cirrhosis enhancing NRF2 signalling pathway [228]