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What Does Smoking Do to Your Arteries? Smoking affects the heart long before symptoms appear. Each cigarette delivers chemicals that enter the bloodstream within seconds, reaching the heart and blood vessels almost immediately. These substances damage the inner lining Tobacco leaves its mark on more than just the lungs. Its effects can extend to the heart, brain, mouth, blood vessels and several other parts of the body, increasing the risk of How Do Tobacco Smoke Affect Cardiovascular Diseases and Blood Vessels

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