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As a result, the residual H 2 O 2 levels may not be sufficient to significantly modulate catalase expression, which could explain the unchanged catalase levels observed following ALA treatment

The researchers hypothesized that weight loss with AOD9604 was driven by the beta-adrenergic pathway, more specifically the beta(3)-adrenergic receptors

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However, previous data demonstrated that the tumor growth suppression and metastases by anti-PD-L1 antibody treatment lacked a complete durable response [110, 113], suggesting the existence of resistance mechanisms