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Muin, D

This not only leads to a significant increase in ROS generation but also further amplifies the local inflammatory response by releasing pro-inflammatory signals (81)

Chung KF (2011) Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids

Essentially, both the presence of thick bronchiolar mucus and bacterial biofilm contribute to poor lung penetration of antimicrobial agents, thus leading to clinical aggravation and inefficacy of the therapies