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Signs that use may be becoming problematic include needing more of the substance to get the same effect, feeling irritable or anxious when not using, using more than intended, and continuing to use even when it causes problems at work, school, or in relationships

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Although the reduction in factors of positive reinforcement, e.g., the expectation to obtain a pleasant sensation from product use, was less pronounced after the use of HTP 1, the differences between products were not statistically significant