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The resulting low testosterone levels further exacerbate impairments in spermatogenesis and metabolic function, thereby perpetuating a vicious cycle ( Diabetes negatively impacts testicular function through multiple mechanisms, including hyperglycemia, oxidative stress, accumulation of AGEs, inflammation, endocrine disruption, ER stress, and mitochondrial dysfunction (112)

Results: The MGBA facilitates bidirectional communication through four major pathways: neural pathways via the vagus nerve, immune pathways via cytokines, endocrine pathways via the HPA axis, and metabolic pathways via short-chain fatty acids and neurotransmitter precursors

Colonic leptin: source of a novel proinflammatory cytokine involved in IBD

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