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10.1016/j.fct.2022.113586 134 KattamisA

PLS-DA models with corresponding values of predictive power (Q 2 ) higher than 0.50 were considered statistically robust

However, it is less effective for treating retinal conditions, primarily due to rapid clearance of drugs from the ocular surface, non-targeted delivery, and the distance between the ocular surface and retina, contributing to a low drug bioavailability in the posterior segment [41]