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It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less

Most multivitamins that contain B12 have 5 to 25 mcg per dose, while supplements that contain only B12 usually have higher doses in the 500 to 3,000 mcg range

Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology