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They found 2812 genes and 149 miRNAs (human and EBV) to be differentially expressed in NP460, HK1, C666, and X666 with RNASeq and 533 miRNA-mRNA target pairs were inversely regulated in the three NPC cell lines compared to NP460 cells

Yet a persistent gap remains between available evidence and routine practice: most neonatal units do not screen for MT-RNR1 variants, extended-interval dosing adoption remains uneven, and model-informed dosing is largely confined to specialist centers