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95 reported elicitation of monoterpene compounds in Thymus species and Zataria multiflora using ZnONPs

It also ameliorated the intensity of the histopathological alterations and improved the immunohistochemical staining of Bcl-2 and caspase-3 proteins in the liver and kidney tissues

To further validate the above discovery, the authors designed two structurally similar fentanyl derivatives FBD1 (partial agonist) and FBD3 (full agonist), with the aim to obtain OR agonists with reduced/abolished -arrestin signaling but relatively intact G protein activity (Figure 6a)

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