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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

This versatility in administration route is practically important because neuropathy often affects diffuse nerve territories rather than a single discrete injury point

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Kim MP, Correa AM, Hofstetter W, Mehran R, Rice DC , Roth JA, Vaporciyan AA, Walsh GL, Erasmus JJ, Swisher SG