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Furthermore, we developed a Methylation-based Resilience Score (MRS) that successfully predicted future cognitive decline in an external dataset from the Alzheimers Disease Neuroimaging Initiative (ADNI), even after accounting for age, sex, APOE 4 , years of education, baseline diagnosis, and baseline MMSE score

Owing to the high blood flow in the kidney and its unique metabolism, it is particularly susceptible to nephrotoxic attack (Nigam et al., 2015)

These findings challenge the traditional natural equals safe paradigm and necessitate evidence-based dosing recommendations

However, it has been found that the pathological degradation of BBB hinders the proper delivery and action of therapeutic agents, due to a series of functional, structural, and biochemical changes at both the endothelial level and, consequently, in the perivascular and interstitial space [314]