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demonstrates that GHK-Cu promotes ECM component synthesis while simultaneously modulating matrix metalloproteinase (MMP) activity (Pickart & Margolina, Biomedicines, 2018)

What is largely missing is the tier that decides clinical questions: randomized, controlled, blinded human trials with objective endpoints

While they are not reviewed or approved by the FDA for safety or effectiveness, they are made in accordance with strict regulatory guidelines

Combined with the Spanish restriction that prohibited non-Spanish shipping the average number of ships going to Alta California from 1770 to 1821 was 2.5 ship/year with 13 years showing no recorded ships