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Please refer to the full prescribing information for pembrolizumab and for carboplatin or cisplatin

View Abstract Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism

Mitochondrial dysfunction in DN is often linked to increased production of ROS, which can lead to oxidative damage and impaired energy metabolism

There is a mounting body of evidence indicating a close association between cellular senescence and the underlying pathophysiology of AKI, as they both exhibit a cell cycle arrest at the G2/M phase, heightened oxidative stress, an increase in cyclin-dependent kinase inhibitors, telomere shortening, and an exacerbated in the fibrotic processes