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Deficiency is also linked to elevated levels of pro-inflammatory cytokines like IL-6 and TNF-, which can sensitize the nerves within the joint

They help improve firmness and elasticity by stimulating collagen production and enhancing cellular hydration

In the same group, B12-downregulated genes had GO annotations related to NF-kappaB signaling, T-cell receptor signaling pathway and negative regulation of histone H3-K9 trimethylation ( Figure S3 )