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Indeed, vitamin D levels were reported to inversely relate to the SLE Disease Activity Index, in which low levels of vitamin D were indicative of greater disease severity (169)

N Engl J Med 1999, 341(18):1336-1343

Safety, dosing, off-target effects, immune responses, and long-term stability are key obstacles that must be addressed in future work

These changes could activate microglia and released pro-inflammatory cytokines, which in turn triggered neuroinflammation and nerve damage (Kannan et al., 2023)