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(2014) confirmed the enrichment of polyphenolic compounds such as naringin and naringenin in grapefruit-derived PDEVs, underscoring the potential contribution of these metabolites to the observed pharmacological activities (Zeng et al., 2018)

The decreased tumour growth in this model is likely due to the specific IGF1R antibodies inhibiting the activation of homodimer IGF1R, but not the insulin/IGF receptor hybrid