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In this context, some of the new formulations of adalimumab have removed or substantially lowered the concentration of the citrate buffer to a residual concentration of 1.2 mM [43, 44], which should minimize or prevent pain potentially associated with this buffer

Neuropathic pain affects 7% to 10% of people in the general population, but it is much higher in people with diabetes between 20% and 30% (Baskozos et al., 2023)