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Indeed, these symptoms, particularly apathy, depression, aggression, personality changes and circadian rhythm disturbances are subtly observed very early in AD (Lyketsos et al., 2011

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10.1016/j.cell.2020.06.034 Cell 14 ChengB.LiT

Thus, these authors examined whether activation of PPAR by GW in activated memory T-cells would shift their metabolism to increase fatty acid oxidation, increase mitochondrial metabolism, and enhance their efficacy for killing tumor cells