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At the same time different neural cells perform distinct functions: more that five hundred million years of nervous system evolution segregated neural cells into electrically excitable neurones responsible for input/output information transfer and information processing and electrically non-excitable neuroglia, 2,3,4 which provide homoeostatic support and defence of the nervous tissue

Studies in the MRL/lpr lupus-prone mouse model have demonstrated that gut dysbiosis can induce intestinal oxidative stress, compromise the gut barrier (evidenced by reduced ZO-2 and elevated fecal albumin and IgA), promote bacterial translocation, and exacerbate systemic inflammation and autoimmune responses [37]

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(2003) Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis