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Although horses can synthesize some choline endogenously, requirements may increase under metabolic stress, high performance demands, or when diets are low in methyl donors such as methionine or folate

This has been reported in two independent studies of catalase-deficient plants using different techniques, despite the fact that the initial increase in H 2 O 2 availability in these systems is expected to be extra-chloroplastic (Smith et al., S -glutathionylation reactions or the TRX system (Dixon et al., 5)

J Clin Invest 120:27152730

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