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In recent years, however, increasing evidence supports dysfunction of the glutaminergic system as being the primary pathophysiological changes seen in schizophrenia [105]

Multiple Cox regression analysis was utilized to assess the hazard ratio (HR) of smoking status with or without passive smoking and smoking pack years for all-cause and disease-specific mortality by adjusting for age, sex, race/ethnicity, alcohol consumption, and comorbidities at baseline survey, such as cancer classification, hypertension, diabetes, hyperlipidemia, and previous CVD events according to smoking status

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Initially, affected persons cough only when performing very strenuous activities